Sunday, May 23, 2010

Child-Turcotte-Pugh and Model for End-Stage Liver Disease (MELD) scoring systems for staging cirrhosis.


 Child-Turcotte-Pugh
and Model for End-Stage Liver
Disease (MELD) scoring systems for staging cirrhosis.

Child-Turcotte-Pugh scoring system
Numerical Score
Parameter123
AscitesNoneSlightModerate to severe
EncephalopathyNoneSlight to moderateModerate to severe
Bilirubin (mg/dL)< 2.02–3> 3.0
Albumin (g/dL)> 3.52.8–3.5< 2.8
Prothrombin time (seconds increased)1–34–6> 6.0
Total numerical score and corresponding Child-Turcotte-Pugh
class
 
Score Class 
5–6A
7–9B
10–15C
MELD scoring system 
MELD = 11.2 loge (INR) + 3.78 loge (bilirubin [mg/dL]) + 9.57 loge (creatinine [mg/dL]) + 6.43 (Range 6–40).


INR, international normalized ratio.

Prognosis

  • Factors determining survival include ability to stop alcohol intake and the Child-Turcotte-Pugh class
  • The Model for End-Stage Liver Disease (MELD) is used to determine priorities for liver transplantation

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